About Applied Photophysics
Applied Photophysics is a world-leading manufacturer and supplier of precision spectrometers for the study of circular dichroism, stopped-flow kinetics and laser flash photolysis. The company supplies the life-sciences community in both academic and commercial spheres with instruments that are used to study the structural, thermodynamic and kinetic properties in solution of a wide range of samples. The current main product range comprises the Chirascan circular dichroism spectrometer, the SX20 stopped-flow spectrometer and the LKS.60 laser flash photolysis spectrometer.
Applied Photophysics' Chirascan is the most advanced circular dichroism spectrometer available today. It is particularly valuable in elucidating the higher structures of bio-macromolecules in solution, for example the secondary structures of proteins, DNA and RNA, and how these structures change when stressed by temperature, pH or other means such as drug binding. Chirascan needs only very small quantities of sample to rapidly and conveniently generate accurate and precise circular dichroism spectra that inform the researcher about the secondary and often the tertiary structures of the system under study. Such structural information is used in establishing if a protein is correctly folded or if proteins from different processes have identical conformations, how higher structures of proteins or DNA change on binding to a drug, whether or not a particular biotherapeutic formulated in one buffer is more stable than in another and many more applications in a similar vein.
The SX20 is Applied Photophysics' world-leading stopped-flow spectrometer and is the preferred choice of at least half the stopped-flow community. It has attained this enviable position by consistently producing excellent results for the transient and pre-steady-state kinetics of fast chemical and biochemical reactions. The range of applications for which it can be used covers virtually all aspects of chemical and biochemical kinetics and typical uses are found in enzyme catalysis and reaction mechanisms, protein refolding on dilution of a denaturant and the kinetics of coordination chemistry. The SX20 and its predecessors the SX17 and SX18 have been used to generate more than 2,000 peer-reviewed scientific papers.
Applied Photophysics' laser flash photolysis spectrometer, the LKS.60, is the modern incarnation of the instrument that started it all. Professor George Porter, later Lord Porter, now deceased but then Director of the Royal Institution of Great Britain, developed laser flash photolysis for the investigation of primary processes and fast chemical reactions and, in response to requests for the supply of instrumentation based on these techniques, Applied Photophysics was formed. Laser flash photolysis provides one of the most effective methods for studying by direct measurement the reactions of transient species such as radicals, excited states or ions, in chemical and biological systems.
Applied Photophysics Limited was established in 1971 by The Royal Institution of Great Britain.
Applied Photophysics Limited
Registered in England 1006739.
203-205 Kingston Road, Leatherhead, KT22 7PB, UK.
Tel.: +44(0)1372 386537 or USA 1-800 543 4130
Fax.: +44(0)1372 386477
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