Are you attending PEGS Boston Virtual 2020? Applied Photophysics will be there exhibiting our Chirascan and SX platforms. Come and see us!
Poster title: A New Approach To Assess Minor HOS Changes With Circular Dichroism
Abstract:
During development of biosimilars and innovator biotherapeutics, the importance of detecting minor changes in higher order structure (HOS) is well recognized. Increasing demands from regulatory authorities for objective, statistically-validatable data present a challenge for certain data types, including circular dichroism (CD) data. Here, we present results from subjecting an IgG1 to a range of degradation conditions, comparing the resulting CD spectra followed by a rigorous statistical analysis. The significance of the differences between the datasets can be objectively evaluated leading to stronger regulatory submissions.