PEGS Boston Virtual 2020

Are you attending PEGS Boston Virtual 2020? Applied Photophysics will be there exhibiting our Chirascan and SX platforms. Come and see us!

Poster title: A New Approach To Assess Minor HOS Changes With Circular Dichroism

Abstract:

During development of biosimilars and innovator biotherapeutics, the importance of detecting minor changes in higher order structure (HOS) is well recognized. Increasing demands from regulatory authorities for objective, statistically-validatable data present a challenge for certain data types, including circular dichroism (CD) data. Here, we present results from subjecting an IgG1 to a range of degradation conditions, comparing the resulting CD spectra followed by a rigorous statistical analysis. The significance of the differences between the datasets can be objectively evaluated leading to stronger regulatory submissions.

Presented by: Marc Neglia, President APP 

Date: Aug 31- Sept 4, 2020

For more information: https://www.pegsummit.com/