Chirascan™ Q100 — Circular Dichroism Spectrometer

Unmatched productivity and performance

Chirascan Q100 provides detailed insight into the Higher Order Structure (HOS) characteristics of complex biomolecules.

Reproducible robotics and high performance circular dichroism spectroscopy combine to generate quality data compatible with the most stringent statistical analysis methods. The result: objective, statistically-validated HOS comparisons.

Fully integrated for unattended operation, Chirascan Q100 saves days of operator time, analyzing 48 buffer-sample pairs over 24 hours whereas an experienced operator processes up to 14 samples per day on a manual system.

Learn more about circular dichroism and HOS of biomolecules

Ready to run

MOLECULAR SIEVE,
ACTIVATED CHARCOAL FILTER

  • Removes common gas impurities

ACTIVE NITROGEN
MANAGEMENT SYSTEM

  • Regulates purge gas consumption
  • Software-controlled

AIR-COOLED XENON LAMP

  • Software-controlled
  • Up-time recorded

MONOCHROMATOR

  • Produces horizontally, linearly polarized ­monochromatic light
  • Dual polarizing prisms maximize light ­throughput

PHOTOELASTIC MODULATOR

  • Converts horizontally polarized light to ­circularly polarized light. ­Alternates between left- and right-handed circular polarized light

INTEGRATED AUTOSAMPLER

  • Eliminate sample handling errors
  • Precise liquid handling and reproducibility
  • Temperature-controlled storage maintains sample integrity

TEMPERATURE-CONTROLLED
SAMPLE CHAMBER

  • Consistent analytical conditions
  • Continuous temperature ramps (single sample mode)

WATER CIRCULATOR

  • Dissipates heat from sample chamber and sample storage Peltiers

AVALANCHE PHOTODIODE DETECTOR

  • Highest sensitivity (high signal: noise)

OPTICS-BASED, MULTIWAVE­LENGTH CALIBRATION

  • For CD accuracy at every wavelength

FIXED FLOW CELLS

  • Eliminates errors of cuvette handling
  • Recognized by Chirascan Control to select run/wash/dry protocols
  • Choice of pathlength to optimize ­concentration and absorbance

CUVETTES AND HOLDERS

  • Selected for far- and near-UV CD analysis of biomolecules (single sample mode)
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HOS Comparison Software

Data obtained on a Chirascan Q100
  • HOS Comparison software enables calculation of weighted spectral difference scores for reference and sample datasets – converting spectra into numerical data.
  • These scores are then exported and used to generate a quality range test or equivalence test as recommended by the FDA.

HOS COMPARISON SOFTWARE

  • Generate statistically-validated ­comparisons
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Control Software

  • Easily defined run parameters and store routine protocols
  • Saves time with scheduled start-up/shutdown of lamp and N2 supply
  • Fail-safe lamp switch-off if N2 flow drops
  • Ensures O2-free conditions with N2 purge
  • Recognizes flow cell to select optimal run/wash/dry protocol
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