Chirascan™ Q100

Unmatched productivity and performance

Chirascan Q100 provides detailed insight into the Higher Order Structure (HOS) characteristics of complex biomolecules.

Reproducible robotics and high performance CD spectrometry combine to generate quality data compatible with the most stringent statistical analysis methods. The result: objective, statistically-validated HOS comparisons.

Fully integrated for unattended operation, Chirascan Q100 saves days of operator time, analyzing 48 buffer-sample pairs over 24 hours whereas an experienced operator processes up to 14 samples per day on a manual system.

Ready to run

MOLECULAR SIEVE,
ACTIVATED CHARCOAL FILTER

  • Removes common gas impurities

ACTIVE NITROGEN
MANAGEMENT SYSTEM

  • Regulates purge gas consumption
  • Software-controlled

AIR-COOLED XENON LAMP

  • Software-controlled
  • Up-time recorded

MONOCHROMATOR

  • Produces horizontally, linearly polarized ­monochromatic light
  • Dual polarizing prisms maximize light ­throughput

PHOTOELASTIC MODULATOR

  • Converts horizontally polarized light to ­circularly polarized light. ­Alternates between left- and right-handed circular polarized light

INTEGRATED AUTOSAMPLER

  • Eliminate sample handling errors
  • Precise liquid handling and reproducibility
  • Temperature-controlled storage maintains sample integrity

TEMPERATURE-CONTROLLED
SAMPLE CHAMBER

  • Consistent analytical conditions
  • Continuous temperature ramps (single sample mode)

WATER CIRCULATOR

  • Dissipates heat from sample chamber and sample storage Peltiers

AVALANCHE PHOTODIODE DETECTOR

  • Highest sensitivity (high signal: noise)

OPTICS-BASED, MULTIWAVE­LENGTH CALIBRATION

  • For CD accuracy at every wavelength

FIXED FLOW CELLS

  • Eliminates errors of cuvette handling
  • Recognized by Chirascan Control to select run/wash/dry protocols
  • Choice of pathlength to optimize ­concentration and absorbance

CUVETTES AND HOLDERS

  • Selected for far- and near-UV CD analysis of biomolecules (single sample mode)
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Control and analysis software

  • Easily defined run parameters and store routine protocols
  • Saves time with scheduled start-up/shutdown of lamp and N2 supply
  • Fail-safe lamp switch-off if N2 flow drops
  • Ensures O2-free conditions with N2 purge
  • Recognizes flow cell to select optimal run/wash/dry protocol

HOS COMPARISON SOFTWARE

  • Generate statistically-validated ­comparisons

GLOBAL THERMODYNAMIC ANALYSIS

  • Derive melting points and enthalpies from multiwavelength, thermal denaturation ­experiments (single sample mode)
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